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99.5% L-Triiodothyronine (T3) CAS 55-06-1 Anti-Aging Steroids for Depressive Disorders
Product Name: L-Triiodothyronine(T3)
CAS No: 55-06-1
Chemical name: 3, 3', 5-Triiodo-L-thyronine, sodium salt
Molecular formula: C15H12I3NO4
Molecular Weight: 650.97
Content: (%): 99
EINECS : 200-223-5
Boiling point: 205
Water-solubility: 4 M NH4OH in methanol: 125 g/5mL, clear, yellow-brown
Appearance: white or light yellow powder, almost tasteless.
Grade : Pharmaceutical Grade
Storage: Shading, confined preservation
Usage : It affects almost every physiological process in the body, including growth and development,metabolism, body temperature, and heart rate, such as, treatment of depressive disorders and use as a fat loss supplement.
Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate. Production of T3 and its prohormone thyroxine (T4) is activated by thyroid-stimulating hormone (TSH), which is released from the pituitary gland. This pathway is regulated via a closed-loop feedback process: Elevated concentrations of T3, and T4 in the blood plasma inhibit the production of TSH in the pituitary gland. As concentrations of these hormones decrease, the pituitary gland increases production of TSH, and by these processes, a feedback control system is set up to regulate the amount of thyroid hormones that are in the bloodstream.
As the true hormone, the effects of T3 on target tissues are roughly four times more potent than those of T4.Of the thyroid hormone that is produced, just about 20% is T3, whereas 80% is produced as T4.
Roughly 85% of the circulating T3 is later formed in the thyroid by removal of the iodine atom from the carbon atom number five of the outer ring of T4. In any case, the concentration of T3 in the human blood plasma is about one-fortieth that of T4. This is observed in fact because of the short half-life of T3, which is only 2.5 days.This compares with the half-life of T4, which is about 6.5 days.
T3 in the body is responsible for regulating the uptake of various nutrients into cells and into the mitochondria of those cells in order to effectively become utilized for the production and consumption of energy.
The mitochondria of every single cell in the body utilizes carbohydrates (primarily), fat, and even protein for the production of an energy source known as ATP (Adenosine Triphosphate). Through the intake of more T3, this production of ATP will increase, leading to an increased rate of energy consumption in the form of fats, carbohydrates, and protein. Hence, this is why the consumption of too much T3 without the use of anabolic steroids can result in muscle loss.
The bodybuilding and athletic world is attracted to the use of T3 as a physique and/or performance enhancing drug because of its capability to distinctly boost the body's metabolism in the effort to metabolize body fat at a greater rate.
T3 is traditionally utilize during cutting, dieting, and/or pre-contest phases of training due to the universal goal of these phases to break down body fat, though in recent years Cytomel has gained some popularity as a useful agent during bulking and mass gaining phases of training (normally in conjunction with anabolic steroids) in order to better efficiently process nutrients and/or to keep body fat levels down during periods of higher caloric intake.
Cytomel (T3) is commonly used with anabolic steroids due to its significant impact on the body's metabolism as a whole. It is very important to understand that T3 is indiscriminate in its metabolism boosting properties - it will increase the metabolism of fats, carbohydrates, and protein all equally.
Therefore, beyond a particular dose of T3, there is an increased risk of muscle loss through increased turnover of protein. Through the use of anabolic steroids and a properly adjusted diet, this muscle loss as a result of T3 can be prevented as a result of the nitrogen-retaining and protein sparing properties of theanabolic steroids.
Cytomel (T3) is also commonly combined with other fat loss agents in order to increase its overall effect, as it does work synergistically with other fat loss agents.
A . Treatment of depressive disorders
The addition of triiodothyronine to existing treatments such as SSRIs is one of the most widely studied augmentation strategies for refractory depression,however success may depend on the dosage of T3. A long-term case series study by Kelly and Lieberman of 17 patients with major refractory unipolar depression found that 14 patients showed sustained improvement of symptoms over an average timespan of two years, in some cases with higher doses of T3 than the traditional 50 µg required to achieve therapeutic effect, with an average of 80 µg and a dosage span of 24 months; dose range: 25-150 µg.The same authors published a retrospective study of 125 patients with the two most common categories of bipolar disorders II and NOS whose treatment had previously been resistant to an average of 14 other medications. They found that 84% experienced improvement and 33% experienced full remission over a period of an average of 20.3 (standard deviation of 9.7). None of the patients experienced hypomania while on T3.
B . Use as a fat loss supplement
3,5-Diiodo-L-thyronine and 3,3'-diiodo-L-thyronine are used as ingredients in certain over-the-counter fat-loss supplements, designed for bodybuilding. Several studies have shown that these compounds increase the metabolization of fatty acids and the burning of adipose fat tissue in rats.
Dosages of T3
In the first approach, the goal is to achieve an ongoing edge in fat loss or to help maintain a near-personally-ideal body composition. In this approach, T3 dosing is very low, preferably 12.5 mcg/day but in some cases as much as 25 mcg/day. At the lower end of this range, typically thyroid testing will show no detectable suppression even with prolonged use. At the higher end, moderate suppression is sometimes seen, but results are superior to when T3 is not taken, and the suppression reverses rapidly upon discontinuing T3 use.
In the second approach, the goal is to achieve a quite substantial increase in rate of fat loss, at the known cost of inducing thyroid suppression. Most preferably the dosage is about 50 mcg/day, but in some instances can be as high as 75 mcg/day. Such use is preferably not ongoing, but only for a limited period of time such as 8-12 weeks, though there's no exact requirement for timeframe.
Triiodothyronine is one of the thyroid hormones present in serum which regulates metabolism. Determination of this hormone
concentration is important for the diagnostic differentiation of euthyroid, hyperthyroid, and hypothyroid states. The major fraction of total triiodothyronine is bound to the transport proteins (TBG, prealbumin, albumin). Free triiodothyronine (fT3) is the physiologically active form of the thyroid hormone triiodothyronine (T3). The determination of free T3 has the advantage of being independent of changes in the concentrations and binding properties of the binding proteins; additional determination of a binding parameter (T-uptake, TBG) is therefore unnecessary. In normal thyroid function, as the concentrations of the carrier proteins alter, the total T3 level changes so that the FT3 concentration remains constant. Thus, measurements of FT3 concentrations correlate more reliably with clinical status than total T3 levels. For example, the increase in total T3 levels associated with pregnancy, oral contraceptives and estrogen therapy result in higher total T3 levels while the FT3 concentration
remains basically unchanged. In addition, it has been found that the mean FT3 value has a gradient decreasin from young to older.
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