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中国 武汉 预定 Pharmaceutical Raw Steroid Sexual Enhancement Ingredients Spironolactone CAS 52-01-7 Oral Chemical Drug  | 价值  ,中国 武汉 Pharmaceutical Raw Steroid Sexual Enhancement Ingredients Spironolactone CAS 52-01-7 Oral Chemical Drug  的信息,Hubei Yuancheng Saichuang Technology Co., Ltd.. 订货人处方的化学产品生产 | Allbiz
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ALL.BIZ中国湖北服务湖北工业化学 科学研究订货人处方的化学产品生产Pharmaceutical Raw Steroid Sexual Enhancement Ingredients Spironolactone CAS 52-01-7 Oral Chemical Drug

Pharmaceutical Raw Steroid Sexual Enhancement Ingredients Spironolactone CAS 52-01-7 Oral Chemical Drug

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预定 Pharmaceutical Raw Steroid Sexual Enhancement Ingredients Spironolactone CAS 52-01-7 Oral Chemical Drug
介绍
Delivery Time: 3~5 days
Payment:Western Union, Money Gram, T/T, Bitcoin
Shipping Method:EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
Grade:Pharmaceutical Grade
Certification:ISO 9001, USP, GMP

 

Pharmaceutical Raw Steroid Sexual Enhancement Ingredients Spironolactone CAS 52-01-7 Oral Chemical Drug 

We are a multifunctional enterprise engaging in fine chemical, flavor and essence, food additive, pharmaceutical intermediates. We have authority of import and export and we have passed ISO9001 in 2008.

Basic Info.

Product Name: Spironolactone
Synonym: Aldactone; Antisterone; Spirolactone; 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21, 17-beta- carbolactone
CAS: 52-01-7
EINECS Number: 200-133-6
Formula: C24H32O4S
MW: 416.5735
Density: 1.24g / cm3
Melting point: 198-207 ℃ (dec.)
Boiling point: 597 ° C at 760 mmHg
Flash Point: 302.2 ° C
Water-soluble: practically insoluble
Vapor Pressure: 3.24E-14mmHg at 25 ° C
Melting point 198-207 ° C (dec.)
Specific rotation -37 ° (c = 1, CHCl3)
Water-soluble practically insoluble
Assay: 98.99%
Appearance: White or almost white fine crystalline powder


Description

Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform.
Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide.

Indications and Usage

Primary hyperaldosteronism for:
Establishing the diagnosis of primary hyperaldosteronism by therapeutic trial.
Short-term preoperative treatment of patients with primary hyperaldosteronism.
Long-term maintenance therapy for patients with discrete aldosterone-producing adrenal adenomas who are judged to be poor operative risks or who decline surgery.
Long-term maintenance therapy for patients with bilateral micro or macronodular adrenal hyperplasia (idiopathic hyperaldosteronism)
Edematous conditions for patients with:Congestive heart failure,Cirrhosis of the liver accompanied by edema and/or ascites,Nephrotic syndrome,Essential hypertension,Hypokalemia,Severe heart failure (NYHA class III - IV)

It can be used as a kind of inefficient diuretic drugs.

It is a synthetic 17-lactone steroid which is a kind of renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension and hypokalemia.

The active metabolite of lactone (spironolactone); It can be used for the Inhibition of aldosterone biosynthesis. It can also be used as the blocker of the Quabain effect.

Pharmacodynamics

Spironolactone is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics. On its own, spironolactone is only a weak diuretic, but it can be combined with other diuretics. Due to its anti-androgen effect, it can also be used to treat hirsutism, and is a common component in hormone therapy for male-to-female transgendered people. Spironolactone inhibits the effect of aldosterone by competing for intracellular aldosterone receptor in the distal tubule cells. This increases the secretion of water and sodium, while decreasing the excretion of potassium. Spironolactone has a fairly slow onset of action, taking several days to develop and similarly the effect diminishes slowly.

Mechanism of action

Spironolactone is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Spironolactone causes increased amounts of sodium and water to be excreted, while potassium is retained. Spironolactone acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents which act more proximally in the renal tubule. Aldosterone interacts with a cytoplasmic mineralocorticoid receptor to enhance the expression of the Na+, K+-ATPase and the Na+ channel involved in a Na+ K+ transport in the distal tubule . Spironolactone bind to this mineralcorticoid receptor, blocking the actions of aldosterone on gene expression. Aldosterone is a hormone; its primary function is to retain sodium and excrete potassium in the kidneys.

Our advantange:
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Professional packing with professional materials, and We'll give clients several Packing way to choose after you contact me through my email
Quality
Our company is a professional leading factory in China in pharmaceutical area, ach batch of steroid powders have to tested by our QC(quality control) department before they are allowed to sell.
Delivery
We can pack your powders within 48 hours after your payment, and corresponding picture of your powders' parcel will be sent to you.
Price
Best prices you're sure to be satisfied, the more you buy, the more competitive prices you get.
Payment
Western Union, Money Gram, T/T, Bitcoin as your convenient.
We are one of the leading manufacturers and exporters in China. We specialized in fine chemical, flavor, food additive, pharmaceutical and intermediates. If you have any questions of our products that you are interested in, please contact as without hesitate.

We are a multifunctional enterprise engaging in fine chemical, flavor and essence, food additive, pharmaceutical intermediates. We have authority of import and export and we have passed ISO9001 in 2008.

Any needs, please feel free to contact me.

 

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